Advanced Pharmacology Exam
Advanced Pharmacology Exam
| Question 1.1. Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to: (Points : 1) |
A need to monitor drugs metabolized by 2D6 for toxicity Increased dosages needed of drugs metabolized by 2D6, such as the SSRIs Decreased conversion of codeine to morphine by CYP 2D6 The need for lowered dosages of drugs, such as beta blockers |
| Question 2.2. Rifampin is a nonspecific CYP450 inducer that may: (Points : 1) |
Lead to toxic levels of rifampin and must be monitored closely Cause toxic levels of drugs, such as oral contraceptives, when co-administered Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure Cause nonspecific changes in drug metabolism |
| Question 3.3. Inhibition of P-glycoprotein by a drug such as quinidine may lead to: (Points : 1) |
Decreased therapeutic levels of quinidine Increased therapeutic levels of quinidine Decreased levels of a co-administered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination Increased levels of a co-administered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination |
| Question 4.4. Warfarin resistance may be seen in patients with VCORC1 mutation, leading to: (Points : 1) |
Toxic levels of warfarin building up Decreased response to warfarin Increased risk for significant drug interactions with warfarin Less risk of drug interactions with warfarin |
| Question 5.5. Pharmacogenetic testing is required by the Food and Drug Administration (FDA) prior to prescribing: (Points : 1) |
Erythromycin Digoxin Cetuximab Rifampin |
| Question 6.6. Patients who have a poor metabolism phenotype will have: (Points : 1) |
Slowed metabolism of a prodrug into an active drug, leading to accumulation of prodrug Accumulation of inactive metabolites of drugs A need for increased dosages of medications Increased elimination of an active drug |
| Question 7.7. Ultra-rapid metabolizers of drugs may have: (Points : 1) |
To have dosages of drugs adjusted downward to prevent drug accumulation Active drug rapidly metabolized into inactive metabolites, leading to potential therapeutic failure Increased elimination of active, nonmetabolized drug Slowed metabolism of a prodrug into an active drug, leading to accumulation of prodrug |
| Question 8.8. When melatonin is used to induce sleep, the recommendation is the patient: (Points : 1) |
Take 10 mg 30 minutes before bed nightly Take 1 to 5 mg 30 minutes before bed nightly Not take melatonin more than three nights a week Combine melatonin with zolpidem (Ambien) for the greatest impact on sleep |
| Question 9.9. Valerian tea causes relaxation and can be used to help a patient fall asleep. Overdosage of valerian (more than 2.5 gm/dose) may lead to: (Points : 1) |
Cardiac disturbances Central nervous system depression Respiratory depression Skin rashes |
| Question 10.10. The standard dosage of St John’s Wort for the treatment of mild depression is: (Points : 1) |
300 mg daily 100 mg three times a day 300 mg three times a day 600 mg three times a day |
| Question 11.11. Licorice root is a common treatment for dyspepsia. Drug interactions with licorice include: (Points : 1) |
Antihypertensives, diuretics, and digoxin Antidiarrheals, antihistamines, and omeprazole Penicillin antibiotic class and benzodiazepines None of the above |
| Question 12.12. Patients should be warned about the overuse of topical wintergreen oil to treat muscle strains, as overapplication can lead to: (Points : 1) |
Respiratory depression Cardiac disturbance Salicylates poisoning Life-threatening rashes |
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