NSG6999 W5 D16 Hypertension Screening

NSG6999 W5 D16 Hypertension Screening

PICOT:  In resistant hypertensive patients, screening with liquid chromatography-tandem mass spectrometry (LC-MS/MS) when compared with self-disclosed adherence, improves blood pressure control and is cost effective as a compliment to optimum standard medication therapy.

 

Azizi, M., Periera, H., Hamdidouche, I., Monge, M., Bobrie, G., Delsart, P., . . .&

Chatellier, G. (2016). Adherence to antihypertensive treatment and the blood

pressure-lowering effects of renal denervation in the Renal Denervation for

Hypertension (DENERHTN) trial. Circulation, 134(12), 847-857.10.1161/

CIRCULATIONAHA.116.022922

 

Why was the study done? Azizi et al. (2016) conducted their study to determine the affect of adherence to prescribed antihypertensive treatment on blood pressure (BP) control. …

 

What is the sample size?  The authors used information and resources from the Renal Denervation for Hypertension (DENERHTN) trial for their data.  In total, 85 patients were screened for medication adherence.

 

Are instruments of the variables in the study clearly defined and reliable?

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How was the data analyzed? 

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Were there any unusual events during the study?  No abnormal or unexpected events were reported by the researchers. …

 

How did the results fit in with the previous research in this area? 

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What are the implications of the research for clinical practice?  

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References

Brinker, S., Pandey, A., Ayers, C., Price, A., Raheja, P., Arbique, D., . . .&

Vongpatanasin (2014). Therapeutic drug monitoring facilitates blood pressure

control in resistant hypertension. Journal of the American College of Cardiology,

63(8), 834-835. doi: 10.1016/j.jacc.2013.10.067

Gupta, P., Patel, P., Strauch, B., Lai, F. Y., Akbarov, A., Gulsin, G. S., . . .Tomaszewski,

1. J. (2017a). Biochemical screening for nonadherence is associated with blood

pressure reduction and improvement in adherence. Hypertension, 70(1), 1042-

1048. doi: 10.1161/HYPERTENSIONAHA.117.09631

Jung, O., Gechter, J. L., Wunder, C., Palke, A., Bartel, C., Geiger, H., & Toennes, S.

1. (2013). Resistant hypertension? Assessment of adherence by toxicological

urine analysis. Journal of Hypertension, 31(4), 766-799. doi: 10.1097/HJH.

0b013e32835e2286

Lawson, A. J., Shipman, K. E., George, S, & Dasgupta, I. (2016). A novel ‘dilute-and-

shoot’ liquid chromatography-tandem mass spectrometry method for screening

of antihypertensive drugs in urine. Journal of Analytical Toxicology, 40(1), 17-

27. doi: 10.1093/jat/bkv102. NSG6999 W5 D16 Hypertension Screening.